Chitosan Oligosaccharide

1. Introduction

Chitosan oligosaccharide powder is a type of oligosaccharide feed additive made from chitin through deacetylation, degradation, and other processes, with a degree of polymerization typically ranging from 2 to 20. It is characterized by strong water solubility and high biological activity. Its raw material, chitin, is widely found in the shells of crustaceans, arthropods, and fungal cell walls, making it abundant and renewable. Chitosan oligosaccharides can exert multifunctional effects by regulating intestinal flora and the immune system, gradually becoming a green additive to replace antibiotics.

Product ingredient:

2. Feature

Safety: No drug residues and antibiotic resistance risks, and metabolites are non-toxic;

Broad-spectrum Function: Combines multiple effects such as promoting growth, regulating the gut, and enhancing immunity;

Efficient Absorption: Small molecular weight, good water solubility, and can be directly utilized by the intestines;

Environmentally Friendly: Improves aquaculture water quality, reduces pollutant emissions from feces;

Stably Applicable: Resistant to high temperatures and acid-base conditions, suitable for various livestock, poultry, and aquatic feed processing.

3. Function

Promote Growth

PerformanceImprove feed utilization, increase daily weight gain and muscle content;Stimulate growth hormone secretion, accelerate protein synthesis.

Regulate Intestinal Health 

Inhibit harmful bacteria such as E. coli and Salmonella, promote the proliferation of Bifidobacterium;Enhance intestinal villus height and crypt depth, improve nutrient absorption capacity.

Enhance Immune Function

Increase the weight of immune organs such as the thymus and bursa of Fabricius;Boost antibody titers and white blood cell activity, reduce disease incidence.

 Replace Antibiotics

Inhibit the adhesion of pathogens, reduce the risk of intestinal infections;Alleviate bacterial resistance issues, ensure food safety.

 Improve Farming Environment

Adsorb ammonia nitrogen and nitrite in water, optimize water quality;Reduce harmful gas emissions from feces.

Regulates intestinal microbiota:
Under acidic conditions, the free amino group protonation in chito-oligosaccharide molecules can interact with the positively charged cell membrane of bacteria, interfering with the function of bacterial cell membranes, causing cytoplasmic loss in bacteria, and inhibiting the growth of fungi and microorganisms. The antibacterial activity of chito-oligosaccharides is related to the strain and concentration. The antibacterial activity is enhanced with an increase in concentration, and it has a bactericidal effect at high concentrations. Chito-oligosaccharides are an important species of beneficial flora, which can regulate the metabolic activities of microorganisms in the intestinal tract of animals, improve the distribution of intestinal microflora, promote the growth and reproduction of bifidobacteria, thereby improving the body's immunity, reducing the pH in the intestine, inhibiting the growth of harmful bacteria in the intestine, producing B vitamins, decomposing carcinogens, promoting intestinal peristalsis, and improving protein absorption.

Improves intestinal tissue morphology:
Chito-oligosaccharide increases the density of ileal microvilli and also tends to become thinner and higher. The increased height and density of microvilli are conducive to increasing the absorption area of the small intestine, promoting the absorption of nutrients, and improving the utilization rate of feed.

Boosts immune function:
The immune-enhancing effect of chito-oligosaccharides has been confirmed by many scholars, and its anti-infective mechanism is explained as follows: Chito-oligosaccharide stimulates the body, promotes the increase in the number of cells in peritoneal exudate, activates macrophages, thereby increasing the production of reactive oxygen species, and then acts through the oxidative bactericidal mechanism. The direct activation of chito-oligosaccharides on macrophages increases the killing activity of macrophages. Chito-oligosaccharide activates T lymphocytes and exhibits killing activity, and sensitized T cells induce delayed hypersensitivity reactions. Chito-oligosaccharides activate T lymphocytes, which in turn lead to the release of macrophage activating factor (MAF), subsequently activating macrophages. During activation, the direct activation of macrophages by chito-oligosaccharide increases its sensitivity to MAF and further activates it. Therefore, it is believed that the production of chito-oligosaccharide killing activity is mainly the result of the activation of T lymphocytes and the enhanced interaction between macrophages.

4. Recommend application
Agriculture

Chito-oligosaccharide alters soil flora, promotes the growth of beneficial microorganisms, and can induce plant disease resistance. It has an immunity and killing effect on various fungi, bacteria, and viruses, effectively controlling wheat mosaic disease, cotton Verticillium wilt, rice blast, tomato late blight, and other diseases. It can be developed as a biological pesticide, growth regulator, and fertilizer.
Daily chemical industry

Chito-oligosaccharide has significant moisturizing properties, activates body cells, prevents skin roughness and aging, inhibits the growth of harmful bacteria on the skin's surface, and absorbs ultraviolet rays. It can be used in moisturizing, anti-wrinkle, and sunscreen products, as well as for maintaining hair surface permeability, moisture, and ease of combing. It also has antistatic, dust-proof, anti-itching, and anti-dandruff properties for use in hair care products.

Biological veterinary drug field
Due to its antibacterial effect, chito-oligosaccharide can prevent or treat animal diseases caused by bacteria such as Staphylococcus aureus, Escherichia coli, Actinobacillus, Streptococcus mutans, etc. It also promotes wound healing, making it suitable for adjuvant treatment of animal trauma or fractures. Its ability to lower blood lipids can be used for the treatment of pet obesity. It also has the potential to create new natural iron, zinc, and calcium supplements due to its good complexing ability with these ions. Chito-oligosaccharide effectively protects rat hepatocytes from cytotoxic damage induced by arsenic trioxide.
Feed additives

Chito-oligosaccharide is non-toxic, non-pyrogenic, and non-mutagenic. It regulates the metabolic activities of microorganisms in the intestinal tract of animals, selectively activates and proliferates the growth of beneficial bacteria, reduces cholesterol and blood lipid content, and improves immunity and lean meat rate. It also hinders the growth and reproduction of pathogenic bacteria, promotes protein synthesis, and cell activation, thereby enhancing the performance of livestock and poultry.

Livestock and Poultry Farming Poultry: Adding 0.1% to broiler feed can increase the Newcastle disease antibody titer and shorten the fattening period; Pigs: Adding chitosan oligosaccharides to the diets of weaned piglets can regulate lipid metabolism and reduce the diarrhea rate.

Aquaculture Fish: Adding 0.2-0.6% can improve the intestinal microbiota balance of tilapia and seabass, repairing intestinal damage;Shrimp: Spraying a chitosan oligosaccharide solution throughout the pond can prevent and control bacterial ulcer disease, enhancing stress resistance.

General Addition Recommendations It is recommended to add 100-150g per ton of feed, adjustable based on animal species and growth stage; Compatibility: It can be used in conjunction with probiotics and enzyme preparations to enhance overall efficacy.

Pharmaceutical field

Chito-oligosaccharide plays a crucial role in immune regulation, anti-tumor activity, hypolipidemic effects, blood sugar regulation, and improvement of liver and cardiopulmonary function.

Food sector
In dairy products, it acts as an activator for intestinal probiotics (e.g., Bifidobacteria) to enhance the absorption of calcium and minerals. In condiments, it serves as a natural preservative to replace chemical preservatives like sodium benzoate. In beverages, it is used in functional drinks for weight loss, detoxification, and immune regulation. For fruits and vegetables, it is used as a coating for freshness, providing permeability, water resistance, and antibacterial and antiseptic effects.

5. Package:

1kg, 25kg

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